The Alzheimer’s Gene Puzzle – The ApoE4 Variant As A Risk Factor

The Alzheimer’s Gene Puzzle – The ApoE4 Variant As A Risk Factor

By Ralph Sanchez, L.Ac.,CNS,D.Hom

Genetic risk factors to late-onset Alzheimer’s disease (LOAD) are significant. A recent study of nearly 12,000 Swedish twin pairs, age 65 and older, determined that 58% to 79% of Alzheimer’s risk is genetic (1). This study showed that in male identical twins, when one brother had Alzheimer’s disease, the other developed the disease 45% of the time. In female identical twins, when one sister had Alzheimer’s disease, the other developed the disease 60% of the time. While this study did not delve into specific gene influences in LOAD, numerous studies have identified Apolipoprotein E4 variant (ApoE4), as a prominent genetic risk factor for LOAD. About 25% of the population has one copy of ApoE4 and carriers with the the ApoE4 variant are estimated to make up approximately 40%-80% of the Alzheimer’s disease population.(2) (more…)

Can Neurotoxins Like Mercury Be Putting You At Risk For Alzheimer’s Disease?

Can Neurotoxins Like Mercury Be Putting You At Risk For Alzheimer’s Disease?

By Ralph Sanchez, MTCM, CNS, D.Hom.

One of the most insidious toxins in our environment is mercury. Mercury is a pervasive toxin that is a staggering environmental problem. It is in our water, food, & air. Without a clear understanding about these routes of exposure and the potential hazard it poses to one’s health, many individuals easily accumulate a mercury body burden over time. Mercury is extremely toxic to brain tissue, and could be a significant risk factor for Alzheimer’s disease (AD) in some individuals. (more…)

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