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THE ALZHEIMER'S SOLUTION

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Lose The Belly Fat And Save Your Brain From Shrinking

Lose The Belly Fat And Save Your Brain From Shrinking

The role of obesity in late-onset Alzheimer’s disease is linked to insulin resistance, type 2 diabetes, cardiovascular disease, and chronic inflammation pathways. Not surprisingly, the same cardiometabolic disease patterns are correlated to brain and hippocampal volumes (brain shrinkage).

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THE ALZHEIMER'S SOLUTION

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THE ALZHEIMER'S SOLUTION

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MEMBER ACCESS: PFAS—The Little-Known Forever Chemicals are Emerging as Dangerous Neurotoxicants

A host of environmental toxins pose a significant health risk to the integrity of your brain (neurotoxins). Neurotoxins are ubiquitous and your exposures to many of them may be passing under your radar. This is especially true of a family ...

MEMBER ACCESS: Mercury Depletes Glutathione Peroxidase-Toxic Mechanisms In Alzheimer’s Disease Risk

The research demonstrating the deleterious and toxic effects of mercury on brain function and structure in neurodegenerative disease processes is plentiful. Adding to the research literature, a May/2009 study demonstrated that methylmercury* induces neurotoxicity, by significantly inactivating one the brain's ...
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MEMBER ACCESS: Oxidative Stress and the Thromboxane Receptor—A Central Pivot in the Production of Neurofibrillary Tangles

New research published Oct. 13 (2014) by the journal Neurobiology of Aging revealed that the free radicals* produced during oxidative stress in Alzheimer's disease (AD) bind to a protein receptor in the brain designated as the: Thromboxane Receptor A2 (TP) ...

MEMBER ACCESS: TREM2 genetic variants in Alzheimer’s disease

Two recently published studies (2013) on a rare variant of the TREM2 gene (triggering receptor expressed on myeloid cells 2), designated as R47H, was shown to increase the risk of developing Alzheimer’s disease. Individuals with the variant may be up ...
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MEMBER ACCESS: Blueberry Polyphenols Protect the Brain from the Degenerative Processes Associated with Brain Aging and Alzheimer’s Disease

The study of plant and fruit polyphenols, a rich source of dietary antioxidants, represents one of the most promising areas of research in the field of anti-aging, and the prevention of degenerative disorders such as Alzheimer's disease. Recent and ongoing ...

MEMBER ACCESS: Brain-Derived Neurotrophic Factor—Growth Factors in Neurogenesis and the Protection Against Alzheimer’s Disease Progression

By Ralph Sanchez, MTCM, CNS, D.Hom. One of the longest held thoughts about damage to our brain's cells (neurons) was that once they were lost, it was a fait accompli. Damaged neurons were considered damaged goods, never to regain their ...

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#betaamyloidandtauprotein #bloodtest #alzheimersrisk"C₂N Diagnostics Releases the PrecivityAD2™ Blood Test for Clinical Care, A Robust Assay with High Concordance to Amyloid PET and CSF"On the heels of the recent announcement by Quest Diagnostics that their blood beta-amyloid test (AD Detect) was now available to the public, C₂N Diagnostics has announced that their innovative PrecivityAD2™ blood test has been launched.C₂N is a molecular diagnostics company, and their new PrecivityAD2™ blood test is a step up on their PrecivityAD™ blood test.Apart from the beta-amyloid 42/40 ratio assessment and ApoE genotype profiling included in the PrecivityAD™ blood test, PrecivityAD2™ adds another set of significant blood biomarkers—phosphorylated and nonphosphorylated forms of the p-tau217 and p-tau181 proteins.The ApoE genotyping profile, however, is not included with PrecivityAD2™.The PrecivityAD2™ beta-amyloid and tau ratio assessments “are combined into a proprietary statistical algorithm to calculate the Amyloid Probability Score 2 (APS2)”, which is an indicator of whether a patient has a high or low probability of the presence of brain amyloid plaques by PET neuroimaging scan.The APS 2 score was developed by C₂N 's proprietary algorithm, and an independent study recently published demonstrated that APS2 was a valid and accurate indicator of amyloid pathology.*Undoubtedly, in the hands of a skilled clinician, the PrecivityAD2™ will now make available to authorized healthcare providers a blood test* with high diagnostic accuracy* in detecting Alzheimer’s disease pathology, and will enable an early assessment approach for individuals with MCI and more severe cognitive impairment.Adding an ApoE genotype profile assessment to PrecivityAD2™ will further support a clinical assessment and evaluation.Several recent and independent studies have shown that p-tau217 and and p-tau218 had “excellent diagnostic performance for differentiating patients with Alzheimer's disease syndromes from other neurodegenerative disorders”,** and a recent study concluded that “were highly specific for amyloid plaque pathology”.***Contact information for C₂N is included in the link here."c2n.com/news-releases/cnnbspdiagnostics-releases-the-precivityad2-blood-test-for-clinical-care---*Independent study demonstrates amyloid probability score accurately indicates amyloid pathology. Fogelman I, West T, Braunstein JB, Verghese PB, Kirmess KM, Meyer MR, Contois JH, Shobin E, Ferber KL, Gagnon J, Rubel CE, Graham D, Bateman RJ, Holtzman DM, Huang S, Yu J, Yang S, Yarasheski KE.Ann Clin Transl Neurol. 2023 May;10(5):765-778. **Advancing Research and Treatment for Frontotemporal Lobar Degeneration investigators. Plasma phosphorylated tau 217 and phosphorylated tau 181 as biomarkers in Alzheimer's disease and frontotemporal lobar degeneration: a retrospective diagnostic performance study. Thijssen EH. et al.,Lancet Neurol. 2021 Sep;20(9):739-752.***Blood plasma phosphorylated-tau isoforms track CNS change in Alzheimer’s diseaseBarthelemy et al.J Exp Med (2020) 217 (11): e20200861.doi.org/10.1084/jem.20200861 ... See MoreSee Less
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THE ALZHEIMER'S SOLUTION

Testimonials

What a tremendous resource! Thank you for putting all of this great research in one place! I am also extremely interested in warding off a family history of Alzheimer’s and Dementia. Medicine can be so very powerful when we are able to identify the biochemical inefficiencies, apply specific dietary and nutritional remedies and compile a protocol to heal not just an individual, but generations. Thank you Ralph!

Tim Walsh LAc

This is an incredible article! Very powerful information! Thank you so much for putting it together the way that you have. This information needs to get out to the masses. You explained that very well.

Dr. Jones

Absolutely the BEST article I have read on the insulin/AD connection. As always, your brilliance is very much appreciated!

Kristin Rotblatt, L.Ac.

Thank you so much for this well written article. Looking forward to future updates. Thanks for this well illustrated, researched, and detailed yet succinct article.

Dr. Shah Roath

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