PREMIUM CONTENT: Insulin, Brain Function And Alzheimer’s Disease – Is Insulin Resistance To Blame For Alzheimer’s?

PREMIUM CONTENT: Insulin, Brain Function And Alzheimer’s Disease – Is Insulin Resistance To Blame For Alzheimer’s?

Insulin fulfills an indispensable role in your body’s utilization of blood sugar (glucose). In type 2 diabetes and Metabolic Syndrome, insulin’s function of glucose uptake into the body’s cells is impaired due to a resistance to insulin that develops over time. This insulin resistance pattern which defines the disease process of the above mentioned disorders, is now seen as a link to the degenerative spiral that occurs in Alzheimer’s disease (AD) over and above the role of insulin in glucose metabolism in the brain. Insulin resistance and its role in inflammation, and impaired insulin function in the brain are now understood to be underlying pieces of the Alzheimer’s puzzle.

Plaques and Tangles in the Alzheimer’s Brain-Which One Is Most To Blame For Alzheimer’s Disease?

Plaques and Tangles in the Alzheimer’s Brain-Which One Is Most To Blame For Alzheimer’s Disease?

The two hallmark lesions that are associated with the damage that occurs in Alzheimer’s disease (AD) are neurofibrillary tangles and amyloid plaques (see pic 1). Processes involving inflammation, oxidative stress, * mitochondrial dysfunction, ** brain cholesterol dynamics (1) and others are tied into the formation of plaques and tangles. However, there has been a long-standing debate in the research community as to whether one lesion or the other is primarily responsible for the AD process.

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