The role of chronic inflammation in degenerative disease associated with aging, is considered to be a primary vector for the progression of said diseases, and a powerful factor that underlies their etiology. One needs only to look at the leading causes of mortality, heart disease and stroke, and the research models of inflammation that clearly link it to the pathogenesis, and the pathology of these disease processes, to understand that inflammation, and chronic degenerative disease are inseparable.
Since inflammation is central to degenerative disease processes, it has been heavily investigated in models of neurodegeneration. In Alzheimer’s disease (AD), the investigation has sought to clarify whether inflammation is a causative stimulus, or a concomitant feature of the disease. Regardless of the etiological focus, inflammation in AD is a well established entity, and the continuing illumination of that knowledge base, is vital to our intent to hopefully prevent, delay, or to develop medical strategies for treatment.