TREM2 gene mutation raises the risk of Alzheimer’s disease

TREM2 gene mutation raises the risk of Alzheimer’s disease

By Ralph Sanchez, MTCM, CNS, D.Hom.

Recently (11/13), a rare variant of the TREM2 gene, designated as R47H, was shown to increase the risk of developing Alzheimer’s disease. Individuals with the variant may be up to 3 to 5 times more likely to develop late-onset Alzheimer’s disease (LOAD). This susceptibility to LOAD in R47H genotypes, is similar to that conferred by the ApoE4 gene.

The TREM2 gene is involved in immune regulatory processes in the brain and the R47H mutation impairs the gene’s ability to contain inflammation. One of the roles of the TREM2 gene that encodes for TREM 2 protein receptor on microglia, is to aid the brain in efficiently eliminating beta amyloid–the toxic protein that forms plaques associated with Alzheimer’s disease. (more…)

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