Alzheimer’s Prevention Trials—The Future Looks Promising
While there is active research for more effective disease-modifying drugs* the lack of any significant breakthroughs in the treatment of the Alzheimer’s disease has propelled a paradigm shift away from focusing solely on a drug solution, to an inclusive prevention model that emphasizes risk reduction and prevention, which promises to attenuate the portentous global burden incurred by the disease.
Current prevalence estimates (2016) for late-onset Alzheimer’s disease (LOAD) in the United States (U.S.) is approximately 5.1 million.(1) By 2050 the projected prevalence of LOAD is expected to escalate to 13.8 million and a staggering 106.8 million worldwide.(2,3) Pharmacological treatments for LOAD such as cholinesterase inhibitors and NMDA receptor antagonists may slow its progression or attenuate specific molecular pathomechanisms associated with the disease process, but are not long term solutions or curative.
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MEMBER ACCESS: Oxidative Stress and the Thromboxane Receptor—A Central Pivot in the Production of Neurofibrillary Tangles
MEMBER ACCESS: TREM2 genetic variants in Alzheimer’s disease
Lead Exposures And Your Brain—A Link Between Lead and Alzheimer’s Disease Risk?
The region of the brain that is most severely affected in Alzheimer’s disease is the hippocampus.
The hippocampus and adjacent structures (hippocampal formation) in the medial temporal lobe of the brain is responsible for turning information we gather from our experiences and environment into memory and learning retention that can be retrieved from the neural networks they are wired into.
As the hippocampus shrinks from the disease processes associated with Alzheimer’s disease, the ability to make new memories vital to everyday tasks are lost. Information processing and memory retention in the hippocampus is dependent on new brain cells (neurons) growing and establishing new connections.
Recent research now reveals that exposures to lead can alter the normal development of newly born neurons (neurogenesis) in this part of the brain vital to learning and memory formation. For more on neurogenesis, please read my article: “Brain-Derived Neurotrophic Factor—Growth Factors in Neurogenesis and the Protection Against Alzheimer’s Disease Progression“. (1) (more…)
MEMBER ACCESS: Blueberry Polyphenols Protect the Brain from the Degenerative Processes Associated with Brain Aging and Alzheimer’s Disease
MEMBER ACCESS: Brain-Derived Neurotrophic Factor—Growth Factors in Neurogenesis and the Protection Against Alzheimer’s Disease Progression
MEMBER ACCESS: Mild Cognitive Impairment (MCI)—Telltale Signs That You May Be At Increased Risk for Dementia or Alzheimer’s Disease
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